2-Cyano-3-fluoropyridine synthesis
- Product Name:2-Cyano-3-fluoropyridine
- CAS Number:97509-75-6
- Molecular formula:C6H3FN2
- Molecular Weight:122.1
38180-46-0
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$6.00/1g
97509-75-6
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$8.00/1g
Yield:97509-75-6 442 mg (50%)
Reaction Conditions:
with potassium fluoride in 1-methyl-pyrrolidin-2-one
Steps:
1 3-Fluoropyrid-2-ylamidoxime
A solution of 2-cyano-3-chloropyridine (1 g, 7.22 mmol) in 1-methyl-2-pyrrolidinone (25 mL) was treated with potassium fluoride (1.26 g, 21.68 mmol) and heated at reflux for 18 hours. After cooling, the reaction was diluted with ethyl acetate and extracted with water and brine. Silica gel chromatography afforded 442 mg (50%) of 2-cyano-3-fluoropyridine.
References:
Wagenen, Bradford Van;Stormann, Thomas M.;Moe, Scott T.;Sheehan, Susan M.;McLeod, Donald A.;Smith, Daryl L.;Isaac, Methvin Benjamin;Slassi, Abdelmalik US2003/55085, 2003, A1
695-37-4
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7677-24-9
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97509-75-6
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152126-32-4
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$108.75/1g
97509-75-6
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51315-07-2
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932-35-4
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97509-75-6
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$8.00/1g
695-37-4
103 suppliers
$60.00/100mg
97509-75-6
277 suppliers
$8.00/1g