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Trimethylsilyl cyanide

Trimethylsilyl cyanide
Trimethylsilyl cyanide structure
Chemical Name:
Trimethylsilyl cyanide
TMSCN;CYANTRIMETHYLSILANE;Trimethycyanosilane;trimethylsilycyanide;TRIMETHYLCYANOSILANE;CYANOTRIMETHYLSILANE;Trimethylsilylcyanid;Trimethylsilyl cyani;TRIMETHYLSILYLNITRILE;Trimethylsilycyanidel
Molecular Formula:
Formula Weight:
MOL File:

Trimethylsilyl cyanide Properties

Melting point:
8-11 °C(lit.)
Boiling point:
114-117 °C(lit.)
0.793 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.392(lit.)
Flash point:
34 °F
storage temp. 
Miscible with organic solvents.
Water Solubility 
Moisture Sensitive
CAS DataBase Reference
7677-24-9(CAS DataBase Reference)
EPA Substance Registry System
Silanecarbonitrile, trimethyl-(7677-24-9)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  F,T+,T,N
Risk Statements  11-26/27/28-29-50/53
Safety Statements  16-36/37/39-45-61-28A-26
RIDADR  UN 3384 6.1/PG 1
WGK Germany  3
Hazard Note  Highly Flammable/Toxic
HazardClass  6.1
PackingGroup  II
HS Code  29310095
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger P264, P270, P301+P310, P321, P330,P405, P501
H310 Fatal in contact with skin Acute toxicity,dermal Category 1, 2 Danger P262, P264, P270, P280, P302+P350,P310, P322, P361, P363, P405, P501
H330 Fatal if inhaled Acute toxicity,inhalation Category 1, 2 Danger P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P320 Specific treatment is urgent (see … on this label).
P330 Rinse mouth.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P405 Store locked up.

Trimethylsilyl cyanide price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 212849 Trimethylsilyl cyanide 98% 7677-24-9 5g $45.3 2018-11-20 Buy
Sigma-Aldrich 212849 Trimethylsilyl cyanide 98% 7677-24-9 25g $131 2018-11-20 Buy
Alfa Aesar A19598 Trimethylsilyl cyanide, 97% 7677-24-9 25g $122 2018-11-13 Buy
Alfa Aesar A19598 Trimethylsilyl cyanide, 97% 7677-24-9 5g $42.3 2018-11-13 Buy
Sigma-Aldrich 73328 Trimethylsilyl cyanide technical, ≥95% (GC) 7677-24-9 250ml-f $683 2018-11-20 Buy

Trimethylsilyl cyanide Chemical Properties,Uses,Production

Chemical Properties

clear colorless to yellow liquid


Reacts with aldehydes and ketones to give cyanohydrin-TMS ethers which can be reduced to β-aminoethyl alcohols.


Trimethylsilyl Cyanide is used as a reagent in the synthesis of optically active cyanohydrins. Used in the preparation of Reissert compounds, which represent reactive polyamides. Toxic to humans.

Purification Methods

The material should have only one sharp signal in the 1H NMR (in CCl4 with CHCl3 as internal standard) : 0.4ppm and IR with max at 2210cm1 [McBride & Beachall J Am Chem Soc 74 5247 1952, Prober J Am Chem Soc 77 3224 1955]; otherwise purify it by fractionating through an 18 x 1/4inch column. [Evers et al. J Am Chem Soc 81 4493 1959.] It has also been carefully distilled using a 60cm vacuum jacketed column. If the volume of sample is small, the cyanide can be chased (in the distillation) with xylene that had been previously distilled over P2O5. It is HIGHLY TOXIC and FLAMMABLE. [Evans et al. J Org Chem 39 914 1974, Beilstein 4 IV 3893.]

Trimethylsilyl cyanide Preparation Products And Raw materials

Raw materials

Preparation Products

Trimethylsilyl cyanide Suppliers

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Trimethylsilyl cyanide Spectrum

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