Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
logo
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
My chemicalbook

Welcome back!

Structured search
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 2-Cyanoethyl 3-oxobutanoate
65193-87-5

2-Cyanoethyl 3-oxobutanoate synthesis

5synthesis methods
Method 1: 1.1 Step 1) 2-cyanoethyl acetoacetate 2,2,6-Trimethyl-4H-1,3-dioxan-4-one (15.50 g, 109.0 mmol), 3-hydroxypropionitrile (7.75 g, 109 mmol) and o-xylene (20 mL)The reaction was carried out at 141 ° C for 2 hours. Cool to room temperature,The solvent was evaporated to give a pale yellow oil (16.63 g, 98.30%).Method 2: 29 That is accurately weighed 1.42g 10mmol of 2,2,6-trimethyl-1,3-dioxin-4-one -4H and 0.82mL Approximately 12mmol of 2-hydroxy-acetonitrile, dissolved in 10mL of ethylene and heated to 140-145 ° C, The reaction was refluxed for 1h, cooled to room temperature, the solvent was removed by rotary evaporation and the residue was purified by flash column chromatography pure Of Compound S711.4g, 90% yield.

2-Cyanoethyl 3-oxobutanoate

5394-63-8 Synthesis
2,2,6-Trimethyl-4H-1,3-dioxin-4-one

5394-63-8
232 suppliers
$19.00/25g

109-78-4 Synthesis
3-Hydroxypropionitrile

109-78-4
385 suppliers
$10.00/1g

2-Cyanoethyl 3-oxobutanoate

65193-87-5
197 suppliers
inquiry

-

Yield:65193-87-5 98.3%

Reaction Conditions:

in o-xylene at 141; for 2 h;

Steps:

1.1 Step 1) 2-cyanoethyl acetoacetate

2,2,6-Trimethyl-4H-1,3-dioxan-4-one (15.50 g, 109.0 mmol), 3-hydroxypropionitrile (7.75 g, 109 mmol) and o-xylene (20 mL)The reaction was carried out at 141 ° C for 2 hours. Cool to room temperature,The solvent was evaporated to give a pale yellow oil (16.63 g, 98.30%).

References:

CN109721596,2019,A Location in patent:Paragraph 0177; 0179-0181

Acetyl ketene

674-82-8
205 suppliers
inquiry

109-78-4 Synthesis
3-Hydroxypropionitrile

109-78-4
385 suppliers
$10.00/1g

2-Cyanoethyl 3-oxobutanoate

65193-87-5
197 suppliers
inquiry

References
Methyl acetoacetate

105-45-3
690 suppliers
$5.00/5g

109-78-4 Synthesis
3-Hydroxypropionitrile

109-78-4
385 suppliers
$10.00/1g

2-Cyanoethyl 3-oxobutanoate

65193-87-5
197 suppliers
inquiry

References
Acetoacetic Acid

541-50-4
56 suppliers
inquiry

109-78-4 Synthesis
3-Hydroxypropionitrile

109-78-4
385 suppliers
$10.00/1g

2-Cyanoethyl 3-oxobutanoate

65193-87-5
197 suppliers
inquiry

References
5-ACETYL-2,2-DIMETHYL-1,3-DIOXANE-4,6-DIONE

72324-39-1
56 suppliers
$130.00/500mg

109-78-4 Synthesis
3-Hydroxypropionitrile

109-78-4
385 suppliers
$10.00/1g

2-Cyanoethyl 3-oxobutanoate

65193-87-5
197 suppliers
inquiry

References

2-Cyanoethyl 3-oxobutanoate Related Search:

Sodium cyanoborohydride Ethyl 3-oxo-4-phenylbutanoate