2-(CYANOMETHYL)BENZOIC ACID synthesis
- Product Name:2-(CYANOMETHYL)BENZOIC ACID
- CAS Number:6627-91-4
- Molecular formula:C9H7NO2
- Molecular Weight:161.16
80070-33-3
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6627-91-4
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Yield: 74%
Reaction Conditions:
Stage #1:2-Hydroxyimino-1-indanon with sodium hydroxide in water at 50;
Stage #2: with p-toluenesulfonyl chloride in water
Stage #3: with hydrogenchloride in water; pH=3 - 4
Steps:
1.b
Indan-l,2-dione-2-oxime (35g, 0.22mol) was added to a solution of 402.5ml 8%NaOH, and the mixture was heated to 500C. Then p-toluenesulfonyl chloride (54.25,0.28mol) was added in portions to the mixture, and the mixture was heated
References:
F. HOFFMANN-LA ROCHE AG WO2007/71348, 2007, A1 Location in patent:Page/Page column 63-64
19821-21-7
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6627-91-4
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15028-10-1
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$45.00/250mg
6627-91-4
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