2-(CYCLOPROPYLMETHOXY)-1H-ISOINDOLE-1,3(2H)-DIONE synthesis
- Product Name:2-(CYCLOPROPYLMETHOXY)-1H-ISOINDOLE-1,3(2H)-DIONE
- CAS Number:113211-15-7
- Molecular formula:C12H11NO3
- Molecular Weight:217.22
524-38-9
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2516-33-8
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113211-15-7
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$130.00/500mg
Yield:113211-15-7 86%
Reaction Conditions:
with triphenylphosphine;diethylazodicarboxylate in tetrahydrofuran at 0; for 15 h;
Steps:
1G
Preparation of N-(cyclopropylmethoxy)phthalimide. To a suspension of cyclopropyl methanol (562 μl, 6.93 mmol), triphenylphosphine (2.02 g, 7.63 mmol) and N-hydroxyphthalimide (1.28 g, 7.63 mmol) in THF (10 mL) at 0° C. was added dropwise diethylazodicarboxylate (1.20 mL, 7.63 mmol) in THF (10 mL). The reaction mixture was allowed to stir for 15 h after which the solvent was removed under vacuum to dryness. Et2O (15 mL) was added to triturate the triphenylphosphine oxide and diethylhydrazinedicarboxylate, which was filtered off and washed with a little Et2O. The ethereal solution was concentrated under vacuum to give a residue which was filtered through a pad of silica (eluting with EtOAc/PE, 3:7). Removal of the solvent under reduced pressure afforded a pale yellow solid which was recrystallized from CH2Cl2/PE to give N-(cyclopropylmethoxy)phthalimide (1.30 g, 86%), as a white solid.
References:
US2006/63841,2006,A1 Location in patent:Page/Page column 26
524-38-9
479 suppliers
$5.00/25g
7051-34-5
411 suppliers
$6.00/1g
113211-15-7
27 suppliers
$130.00/500mg