Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List (Bromomethyl)cyclopropane
7051-34-5

(Bromomethyl)cyclopropane synthesis

10synthesis methods
Cyclopropyl carbinol

2516-33-8

(Bromomethyl)cyclopropane

7051-34-5

Example 1 (control experiment): 1250 mL of dimethylformamide (DMF) was added to the reaction vessel under nitrogen protection, followed by 280.8 g of triphenylphosphine. 70 g of hydroxymethylcyclopropane was added with stirring and the reaction was carried out at room temperature for 30 minutes. After cooling the reaction solution to -10°C, 158.3 g of bromine (102% of the theoretical amount) was slowly added dropwise over a period of 4 hours. Upon completion of the reaction, the reaction mixture was purified by distillation to afford bromomethylcyclopropane in 77.5% yield (based on theoretical values) with a product purity of >97%, which contained 0.6% open-chain haloalkanes.

-

Yield:7051-34-5 77.5%

Reaction Conditions:

with bromine;triphenylphosphine in N-methyl-acetamide

Steps:

1 Example 1
Example 1 (for comparison) 1250 ml of dimethylformamide were placed into the reaction vessel, and then 280.8 g of triphenylphosphine and then 70 g of hydroxymethylcyclopropane were added, the mixture was stirred for 30 minutes at room temperature under a nitrogen atmosphere, and the solution was subsequently cooled to -10° C. Then, 158.3 g of bromine (that is to say 2 mol % more than theoretically required) were metered in in the course of 4 hours. The reaction mixture was worked up by distillation. Bromomethylcyclopropane was obtained in a yield of 77.5% of theory. The purity of the product was over 97%, the open-chain halogenoalkanes amounted to 0.6%.

References:

Bayer Aktiengesellschaft US6008420, 1999, A

FullText

(Bromomethyl)cyclopropane Related Search: