2-(DiMethylaMino)propane-1,3-diol synthesis
- Product Name:2-(DiMethylaMino)propane-1,3-diol
- CAS Number:78531-45-0
- Molecular formula:C5H13NO2
- Molecular Weight:119.16
Yield:78531-45-0 68.65%
Reaction Conditions:
with formic acid at 20 - 80;
Steps:
1
45.6 g of 2-amino-1,3-dihydroxypropane was mixed with 113 mL of formic acid solution,Then add 90 mL of 37% formaldehyde solution.The mixture was stirred at room temperature for 2h,The reaction was then warmed to 80 ° C,And kept at this temperature overnight.When the temperature reaches 80 , there will be a lot of gas discharge. After the reaction was completed, it was cooled to room temperature. 60 mL of 37% strength hydrochloric acid was added and stirred for 1 h.Solid sodium hydroxide was added to adjust the pH of the solution to 12, the mixture was distilled under reduced pressure,Add a lot of methanol.At this point the white precipitate generated in the system filter, the filtrate was distilled off under reduced pressure,The concentrated initial product was dissolved in trichloromethane and dried over anhydrous magnesium sulfate.In the conditions of 100 -102 / 100Kpa by distillation,40.9 g was obtained2-N, N-dimethyl-1,3-dihydroxypropane,The yield was 68.65%.
References:
CN105198773,2017,B Location in patent:Paragraph 0024; 0027-0030
534-03-2
473 suppliers
$7.00/10g
78531-45-0
38 suppliers
inquiry
