2-fluoro-4-(methylthio)benzonitrile synthesis
- Product Name:2-fluoro-4-(methylthio)benzonitrile
- CAS Number:411233-39-1
- Molecular formula:C8H6FNS
- Molecular Weight:167.2
Yield:411233-39-1 100%
Reaction Conditions:
with potassium carbonate in acetonitrile at 20; for 3 h;
Steps:
AE.iv
Methyl iodide (12.5 g, 0.058 mol) was added dropwise to a solution of 2-fluoro-4-mercaptobenzonitrile (9 g, 0.058 mol) (from step (iii) above and potassium carbonate (12.1 g, 0.088 mol) in dry acetonitrile (150 ml) and stirred at room temperature for 3 h under nitrogen atmosphere. The reaction mixture was filtered and the filtrate was concentrated to give the sub-title compound (9.6 g, 100%)
References:
US2008/15237,2008,A1 Location in patent:Page/Page column 35-36
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