2-(Methanesulfonylamino)benzonitrile synthesis
- Product Name:2-(Methanesulfonylamino)benzonitrile
- CAS Number:50790-29-9
- Molecular formula:C8H8N2O2S
- Molecular Weight:196.23
![2-[Bis(Methylsulfonyl)aMino]benzonitrile](/CAS/GIF/235100-91-1.gif)
235100-91-1
18 suppliers
inquiry
50790-29-9
26 suppliers
inquiry
Yield:50790-29-9 92%
Reaction Conditions:
Stage #1: 2-
Stage #2: with hydrogenchloride in tetrahydrofuran;water;
Steps:
1 Preparation of N-(2-Aminomethyl-phenyl)-methanesulfonamide acetate (B7)
Step 1. Preparation of N-(2-cyano-phenyl)-methanesulfonamide (B7-1): A solution of B6-1 (4 g, 14.8 mmol) in THF (29.26 mL) was treated with 40% aqueous NaOH (29.26 mL) and BTEAC (0.331 g, 1.45 mmol) and stirred at 25° C. for 20 hours. The reaction mixture was then concentrated, and the resultant residue was diluted with water (100 mL) and neutralized with 6N HCl (30 mL). The mixture was extracted with DCM (200 mL), and the organic layer was washed with water (150 mL) and brine. The organic solution was then dried over anhydrous sodium sulfate and concentrated to provide B7-1 as a white solid. Yield: 2.8 g, 92%. 1H NMR (CDCl3): δ 7.7-7.76 (m, 1H), 7.6-7.65 (m, 1H), 6.8-6.98 (broad, 1H) and 3.14 (s, 3H). Mass: (M-1) 195 calculated for C8H8N2O2S.
References:
US2009/54395,2009,A1 Location in patent:Page/Page column 38
1010691-05-0
1 suppliers
inquiry
50790-29-9
26 suppliers
inquiry
124-63-0
0 suppliers
$10.00/5g
1885-29-6
454 suppliers
$5.00/1g
50790-29-9
26 suppliers
inquiry
235100-91-1
18 suppliers
inquiry