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ChemicalBook CAS DataBase List 2-METHYL-D3-PROPIONIC ACID

2-METHYL-D3-PROPIONIC ACID synthesis

3synthesis methods
802294-64-0 Synthesis
Propionic-2,3-14C1 acid (8CI)

802294-64-0
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Yield:95926-99-1 62%

Reaction Conditions:

Stage #1: propionic acidwith lithium diisopropyl amide in tetrahydrofuran at 0 - 80; for 2 h;Inert atmosphere;
Stage #2: iodomethane-d3 in tetrahydrofuran at 0 - 80; for 10 h;

References:

WO2019/233447,2019,A1 Location in patent:Page/Page column 96-97