2-Methylenecyclopentanone synthesis

12synthesis methods

Product Name:2-Methylenecyclopentanone
CAS Number:1489-50-5
Molecular formula:C6H8O
Molecular Weight:96.13

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Yield:-

Reaction Conditions:

with paraformaldehyde in tetrahydrofuran

Steps:

14.a 6-({4-[(2-methyl-4-quinolinyl)methoxy]phenyl}sulfonyl)methyl]-1,3-diazaspiro[4.4]nonane-2,4-dione
(14a) A solution of cyclopentanone (2.0 g, 23.8 mmol), paraformaldehyde (2.0 g), and N-methylaniline trifluoroacetic acid salt (12.7 g, 57.4 mmol) in 25 mL of THF was refluxed for 15 min and then partitioned between ether and 2*1N HCl and separated. The organic phase was dried over MgSO₄, filtered, and concentrated on a rotary evaporator to give 2-methylene-cyclopentanone.

References:

Sheppeck, James E.;Duan, Jingwu;Xue, Chu-Biao;Wasserman, Zelda US2003/130273, 2003, A1