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ChemicalBook CAS DataBase List 2-MORPHOLIN-4-YL-4-PHENYL-THIAZOLE-5-CARBALDEHYDE
129880-85-9

2-MORPHOLIN-4-YL-4-PHENYL-THIAZOLE-5-CARBALDEHYDE synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: acetonitrile / 3 h / Reflux
1.2: 0.5 h / 20 °C
2.1: TEA / ethanol / 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C
4.1: manganese(IV) oxide / dichloromethane / 1 h / 0 °C

References:

Swain, Baijayantimala;Singh Digwal, Chander;Angeli, Andrea;Alvala, Mallika;Singh, Priti;Supuran, Claudiu T.;Arifuddin, Mohammed [Bioorganic and Medicinal Chemistry,2019,vol. 27,# 21,art. no. 115090]

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