2-Morpholin-4-yl-4-phenyl-thiazole-5-carboxylic acid ethyl ester synthesis
- Product Name:2-Morpholin-4-yl-4-phenyl-thiazole-5-carboxylic acid ethyl ester
- CAS Number:55040-86-3
- Molecular formula:C16H18N2O3S
- Molecular Weight:318.39
110-91-8
710 suppliers
$9.00/1g
532-55-8
215 suppliers
$9.00/1g
762-21-0
250 suppliers
$24.00/5G
55040-86-3
10 suppliers
inquiry
Yield:55040-86-3 52%
Reaction Conditions:
with porcine pancreas trypsin in ethanol at 45; for 7 h;Enzymatic reaction;
Steps:
3.2. General Procedure for the Synthesis of Thiazole Derivatives
General procedure: A mixture of secondary amine (1.0 mmol), benzoyl isothiocyanate (1.0 mmol), dialkyl acetylenedicarboxylate (1.0 mmol), trypsin from porcine pancreas (PPT, 20 mg) and ethanol (5 mL),was introduced to a test tube (10 mL), then the mixture was placed on a shaker under 160 rpm end-over-end rotation at 45°C for 7 h. The reaction mixture was monitored by TLC to the endpoint.The solution was then filtered through paper and the solvent was evaporated. The residue was purified on silica gel (hexane/EtOAc = 4:1 as eluent) to afford the target compounds. The compounds 4a-j are known [7,20] and compounds 4c and 4k are new, and were additionally characterized by elemental analysis.
References:
Zheng, Hui;Mei, Yi-Jia;Du, Kui;Cao, Xian-Ting;Zhang, Peng-Fei [Molecules,2013,vol. 18,# 11,p. 13425 - 13433]
98-88-4
598 suppliers
$10.00/5g
55040-86-3
10 suppliers
inquiry
![4-Morpholinecarbothioamide, N-[phenyl(phenylimino)methyl]-](/CAS/20180601/GIF/5093-29-8.gif)