2-(o-tolyl)piperidine synthesis
1synthesis methods
- Product Name:2-(o-tolyl)piperidine
- CAS Number:118576-99-1
- Molecular formula:C12H17N
- Molecular Weight:175.27
Yield:118576-99-1 50%
Reaction Conditions:
Stage #1: piperidinewith n-butyllithium in diethyl ether;hexane at -78; for 0.0833333 h;Inert atmosphere;
Stage #2: with 2,2,2-Trifluoroacetophenone in diethyl ether;hexane at -78; for 0.166667 h;Inert atmosphere;
Stage #3: 2-methylphenyl bromidewith n-butyllithium in diethyl ether;hexane at -78 - 20; for 4 h;Inert atmosphere;
References:
Paul, Anirudra;Kim, Jae Hyun;Daniel, Scott D.;Seidel, Daniel [Angewandte Chemie - International Edition,2021,vol. 60,# 3,p. 1625 - 1628][Angew. Chem.,2021,vol. 133,# 3,p. 1649 - 1652,4] Location in patent:supporting information