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ChemicalBook CAS DataBase List 2-O-TOLYL-SUCCINIC ACID
91143-76-9

2-O-TOLYL-SUCCINIC ACID synthesis

5synthesis methods
-

Yield:91143-76-9 83.2%

Reaction Conditions:

Stage #1: chloroacetic acidwith potassium carbonate in N,N-dimethyl-formamide;
Stage #2: 2-tolylmethylnitrilewith potassium hydroxide in N,N-dimethyl-formamide at 20 - 25; for 2 h;
Stage #3: with sodium hydroxide for 16 h;Heating;

References:

Makosza;Marcinowicz [Synthesis,2001,# 9,p. 1311 - 1312]