2-OXO-1-PYRROLIDINEACETIC ACID METHYL ESTER synthesis
- Product Name:2-OXO-1-PYRROLIDINEACETIC ACID METHYL ESTER
- CAS Number:59776-88-4
- Molecular formula:C7H11NO3
- Molecular Weight:157.17
Yield: 54.15%
Reaction Conditions:
Stage #1:2-pyrrolidinon with sodium hydride in tetrahydrofuran;mineral oil at 0; for 0.5 h;
Stage #2:bromoacetic acid methyl ester in tetrahydrofuran;mineral oil at 20; for 2 h;
Steps:
69 Synthesis of compound 69.2.
To the suspension of sodium hydride (1.69g, 70.58mmol, 1.2eq) in tetrahydrofuran (25mL) at 0°C was added solution of 69 (5.0g, 58.82mmol, 1.0eq) in tetrahydrofuran (25mL) dropwise. Reaction mixture was stirred at room temperature for 30min. Then 69.1 (10.7g, 70.58mmol, 1.2eq) was added in to reaction mixture and stirred at room temperature for 2h. After completion of reaction, reaction mixture was transferred into ice cold water and product was extracted with ethyl acetate. Organic layer was combined, washed with brine solution, dried over sodium sulfate and concentrated under reduced pressure to obtain 69.2. (5.0g, Yield: 54.15percent). MS(ES): m/z 157.07 [M+H] +.
References:
NIMBUS LAKSHMI, INC.;GREENWOOD, Jeremy Robert;MASSE, Craig E. WO2020/112937, 2020, A1 Location in patent:Paragraph 00766
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