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Description References
2-Pyrrolidinone structure
Chemical Name:
2-P;α-PVR;2-Pyrol;Pyrrolidon;Soluphor P;Pyrrolidone;-Pyrrolidone;2-pyrolidone;BUTYROLACTAM;2-PYRROLIDON
Molecular Formula:
Formula Weight:
MOL File:

2-Pyrrolidinone Properties

Melting point:
23-25 °C(lit.)
Boiling point:
245 °C(lit.)
1.12 g/mL at 25 °C(lit.)
vapor density 
2.9 (vs air)
vapor pressure 
0.04 hPa (20 °C)
refractive index 
n20/D 1.487(lit.)
Flash point:
>230 °F
storage temp. 
H2O: miscible (completely)
Liquid or Low Melting Mass
Clear colorless to pale yellow
9-11 (100g/l, H2O, 20℃)
explosive limit
Water Solubility 
CAS DataBase Reference
616-45-5(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Risk Statements  22
Safety Statements  24/25
RIDADR  2810
WGK Germany  1
RTECS  UY5715000
Autoignition Temperature 395 °C
HazardClass  6.1(b)
PackingGroup  III
HS Code  29339980
Hazardous Substances Data 616-45-5(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: > 3200 mg/kg
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.

2-Pyrrolidinone price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 240338 2-Pyrrolidinone ≥99% 616-45-5 50g $53.3 2018-11-13 Buy
Sigma-Aldrich 83300 2-Pyrrolidinone purum, ≥98.0% (GC) 616-45-5 1l $69.1 2018-11-13 Buy
TCI Chemical P0575 2-Pyrrolidone >98.0%(GC) 616-45-5 25g $14 2018-11-22 Buy
TCI Chemical P0575 2-Pyrrolidone >98.0%(GC) 616-45-5 500g $33 2018-11-22 Buy
Alfa Aesar A15332 2-Pyrrolidinone, 99% 616-45-5 500g $27.8 2018-11-13 Buy

2-Pyrrolidinone Chemical Properties,Uses,Production


2-pyrrolidone carboxylic acid, also known as pyroglutamic acid, is a derivative of the glutamine and glutamate. It is contained in many kinds of proteins including bacteriorhodopsin. It is a nonessential nutrient which can be normally generated during the glutathione cycle process inside the human body. It is also contained in fruits and vegetables. Pyroglutamic acid has many physiological functions and healthy effects. Its L-form can increase the activity off neurotransmitter acetylcholine and can be used in the production of the neurotransmitters gramma-aminobutyric acid (GABA) as well as glycine. Based on this, L-pyroglutamic acid is beneficial to brain function, being capable of supporting memory and learning as well as alleviating anxiety. In addition, its sodium-form product (sodium pyroglutamate), as a humectant, can be used for dry skin and hair products.


Chemical Properties

Clear colorless liquid or low melting solid

Chemical Properties

2-Pyrrolidone undergoes the reactions of a typical lactam, e.g. ring opening, attack on the carbonyl group, and replacement of hydrogens alpha to the carbonyl group. Strong acids and bases catalyze the hydrolysis of 2-pyrrolidone to 4-aminobutanoic acid (GABA). The hydrogen atom on the nitrogen atom is easily replaced by alkylation reactions with alkyl halide or sulfates, or reaction with acid anhydrides, acyl halides, ethylene oxide, and styrene. Condensation reactions with secondary amines and alcohols, and O-alkylation reactions occur at the carbonyl group. In the presence of anionic catalyst systems, 2-pyrrolidone is polymerized to polypyrrolidone, nylon-4 (Hort and Anderson 1978).

Chemical Properties

Pyrrolidone occurs as a colorless or slightly grayish liquid, as white or almost white crystals, or colorless crystal needles. It has a characteristic odor.


2-Pyrrolidinone is a widely used organic polar solvent for various applications. 2-Pyrrolidinone is also an intermediate in the manufacture of polymers.


ChEBI: The simplest member of the class of pyrrolidin-2-ones, consisting of pyrrolidine in which the hydrogens at position 2 are replaced by an oxo group. The lactam arising by the formal intramolecular condensation of the amino and carboxy groups of gamm -aminobutyric acid (GABA).

Production Methods

The synthesis of 2-pyrrolidone was first reported in 1889 as the product of dehydration of 4-aminobutanoic acid. It is produced commercially by condensation of butyrolactone with ammonia, a method first described in 1936. Other synthetic routes include carbon monoxide insertion into allylamine, hydrolytic hydrogenation of succinonitrile, and hydrogenation of ammoniacal solutions of maleic and succinnic acids (Hort and Anderson 1978).

Production Methods

Pyrrolidone is prepared from butyrolactone by a Reppe process, in which acetylene is reacted with formaldehyde.

Health Hazard

Exposure to 2-pyrrolidone produces irritation to the eyes, mucous membranes, and skin. Although reported to be a skin sensitizer in animal tests, there is no indication that 2-pyrrolidone is a skin sensitizer in human exposures (Anon 1975). 2-Pyrrolidone has been reported to enhance the permeability of human skin for methanol, but reduced the permeability for octanol (Southwell et al 1983).

Pharmaceutical Applications

Pyrrolidone and N-methylpyrrolidone are mainly used as solvents in veterinary injections. Pyrrolidone has been shown to be a better solubilizer than glycerin, propylene glycol, or ethanol. They have also been suggested for use in human pharmaceutical formulations as solvents in parenteral, oral, and topical applications. In topical applications, pyrrolidones appear to be effective penetration enhancers. Pyrrolidones have also been investigated for their application in controlled-release depot formulations.

Industrial uses

2-Pyrrolidone is used as an intermediate for synthesis of l-vinyl-2-pyrrolidone and various TV-methylol derivatives used as textile-finishing agents; as a solvent for various polymers, chlordane and DDT, d-sorbitol, glycerin, and sugars; and as a decolorizing agent for kerosene, fatty oils, and rosins. N-methyl-2-pyrrolidone and 2-pyrrolidone are utilized in petroleum refining to selectively extract aromatics from paraffinic hydrocarbons. 2-Pyrrolidone is used as a plasticizer and coalescing agent for acrylic latices and acrylic/styrene copolymers in emulsion coatings, i.e. floor waxes. A linear high molecular weight polyamide polymer of 2-pyrrolidone, nylon-4, is used as a textile fiber, injection molding compound, and film-forming polymer (Anon. 1975; Hort and Anderson 1978).


Pyrrolidones are mainly used in veterinary injections and have also been suggested for use in human oral, topical, and parenteral pharmaceutical formulations. In mammalian species, pyrrolidones are biotransformed to polar metabolites that are excreted via the urine. Pyrrolidone is mildly toxic by ingestion and subcutaneous routes; mutagenicity data have been reported.
LD50 (guinea pig, oral): 6.5 g/kg
LD50 (rat, oral): 6.5 g/kg


A metabolite of 2-pyrrolidone, 4-aminobutanoic acid has been identified in animals (Lundgren et al 1980). 2-Pyrrolidone has been reported to be an endogenous constituent in the brains of mice (Callery et al 1978) and bovine (Mori et al 1975). The aliphatic polyamine putrescine has been demonstrated to be metabolized to 2-pyrrolidone in rat liver slices (Lundgren and Hankins 1978; Lundgren et al 1985) and to lesser extent by slices of spleen and lung, but not in tissue slices from kidney, brain, heart, or rear leg muscle (Lundgren and Hankins 1978). The metabolism of putrescine is catalyzed by the microsomal enzyme diamine oxidase (EC to 4-aminobutyraldehyde, which is subsequently oxidized to the neurotransmitter 4-aminobutanoic acid (4-aminobutyric acid, GAB A) or is cyclized to delta1-pyrroline (Seiler 1980; Lundgren et al 1980; Callery et al 1980), which is in turn oxidized to 5-hydroxy-2-pyrrolidone (Lundgren and Fales 1980). There is evidence that 5-hydroxy-2-pyrrolidone is further metabolized to succinimide, malimide, 2- and 3-hydroxysuccinamic acids, maleamic acid, and carbon dioxide (Bandle et al 1984). An enzyme system residing in the soluble fraction of rabbit liver catalyzes the conversion of delta'-pyrroline to ?-aminobutyric acid and its lactam, 2-pyrrolidone (Callery et al 1982). 2-Pyrrolidone has been identified as a urinary metabolite of N-nitrosopyrrolidine (Cottrell et al 1980) and the drug methadone (Kreek 1980).


Pyrrolidone is chemically stable and, if it is kept in unopened original containers, the shelf-life is approximately one year. Pyrrolidone should be stored in a well-closed container protected from light and oxidation, at temperatures below 20°C.


Pyrrolidone is incompatible with oxidizing agents and strong acids.

2-Pyrrolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

2-Pyrrolidinone Suppliers

Global( 249)Suppliers
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Hefei TNJ Chemical Industry Co.,Ltd.
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View Lastest Price from 2-Pyrrolidinone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-16 2-Pyrrolidinone
US $7.00 / kg 1kg 99% 100kg career henan chemical co
2018-08-20 2-Pyrrolidinone
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-07-26 2-Pyrrolidinone
US $100.00 / KG 1KG 99% Customized career henan chemical co

2-Pyrrolidinone Spectrum

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