2-(Pentafluoroethyl)benzimidazole synthesis
- Product Name:2-(Pentafluoroethyl)benzimidazole
- CAS Number:383-08-4
- Molecular formula:C9H5F5N2
- Molecular Weight:236.14
Yield:383-08-4 100%
Reaction Conditions:
for 4 h;Reflux;
Steps:
7 Example 7
Production of 2-pentafluoroethylbenzimidazole
To a 50 mL eggplant-shaped flask equipped with a magnetic stirrer, 3.2 g (30 mmol) of 1,2-phenylenediamine and 9.8 g (60 mmol) of pentafluoropropionic acid were added.
The mixture was heated to reflux for 4 hours.
After cooling, the reaction mixture was poured into an aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate.
The ethyl acetate layer was washed with a saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure to obtain 7.3 g of crystals. Yield: 100%.
1H-NMR (400 MHz, CDCl3, relative to TMS) δ (ppm): 7.43 (m, 2H), 7.58 (m, 1H), 7.92 (m, 1H), 9.87 (br, 1H).
References:
US2017/197920,2017,A1 Location in patent:Paragraph 1219-1221
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