2-Phenoxy-pyriMidine-5-carboxylic acid synthesis
- Product Name:2-Phenoxy-pyriMidine-5-carboxylic acid
- CAS Number:927877-48-3
- Molecular formula:C11H8N2O3
- Molecular Weight:216.19
1068975-32-5
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Yield:927877-48-3 73%
Reaction Conditions:
Stage #1: 2-phenoxy-pyrimidine-5-carboxylic acid methyl esterwith lithium hydroxide;water in tetrahydrofuran at 0; for 1 h;
Stage #2: with hydrogenchloride in water;
Steps:
58.3
Step 3: To a solution of 2-phenoxy-pyrimidine-5-carboxylic acid methyl ester (0.5 g, 2.17 mmol) in THF (10 mL) and water (5 mL) is added LiOH (105 mg, 4.35 mmol). The reaction is stirred at O0C for 1 h. The THF is evaporated and the aqueous reissue is washed with ether, acidified with 2 M aqueous HCl. The resulting precipitate is filtered and dried to afford I1 phenoxy-pyrimidine-5 -carboxylic acid (0.34g, 73%) as a solid. MS: 217 (M+H); 1H NMR (300 MHz, CDCl3): δ 7.20-7.35 (m, 3H), 7.47 (t, 2H) 9.16 (s, 2H).
References:
WO2008/121670,2008,A1 Location in patent:Page/Page column 99
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