ChemicalBook CAS DataBase List 2-Phenyl-7-BroMoquinoline

2-Phenyl-7-BroMoquinoline synthesis

10synthesis methods

Product Name:2-Phenyl-7-BroMoquinoline
CAS Number:1203578-65-7
Molecular formula:C15H10BrN
Molecular Weight:284.15

946122-05-0

98-86-2

1203578-65-7

General procedure for the synthesis of 2-phenyl-7-bromoquinoline from (2-amino-4-bromophenyl)methanol and acetophenone: acetophenone (144 mg, 1.2 mmol), [Cp*Ir(6,6'-(OH)2bpy)(H2O)][OTf]2 (8.3 mg, 0.01 mmol, 1 mol%), potassium hydroxide (56 mg, 1.0 mmol, 1.0 equiv), 2-amino-4-bromobenzyl alcohol (201 mg, 1.0 mmol), and water (1 mL) were added sequentially to a 5 mL round bottom flask. The reaction mixture was refluxed in air for 12 h and then cooled to room temperature. The reaction mixture was extracted with ethyl acetate, the organic solvent was removed by rotary evaporation, and then purified by column chromatography (unfolding agent: petroleum ether/ethyl acetate) to afford pure 2-phenyl-7-bromoquinoline in 94% yield.

946122-05-0 Synthesis

946122-05-0
72 suppliers
$24.00/250mg

98-86-2 Synthesis

98-86-2
794 suppliers
$9.00/5g

1203578-65-7
52 suppliers
$45.00/10mg

Yield:1203578-65-7 94%

Reaction Conditions:

with [(η⁵-C₅Me₅)Ir(6,6'-dihydroxy-2,2'-bipyridine)(H₂O)]OTf₂;potassium hydroxide in water; for 12 h;Reflux;Green chemistry;

Steps:

24 7-bromo-2-phenylquinoline

Acetophenone (144 mg, 1.2 mmol),[Cp * Ir (6,6 '- (OH) 2bpy) (H2O)] [OTf] 2 (8.3mg, 0.01mmol, 1mol%), potassium hydroxide (56mg, 1.0mmol, 1.0 equiv.),2-Amino-4-bromobenzyl alcohol (201 mg, 1.0 mmol) and water (1 mL) were sequentially added to a 5 mL round bottom flask. After the reaction mixture was refluxed in air for 12 hours,Cool to room temperature. It was extracted with ethyl acetate, the solvent was removed by rotary evaporation and then purified by column chromatography (developing solvent: petroleum ether / acetic acidEthyl ester) to give the pure target compound in a yield of 94%

References:

CN107400084,2017,A Location in patent:Paragraph 0141; 0142; 0143

59278-65-8 Synthesis