2-Propanone, 1-chloro-3-(4-fluorophenyl)- synthesis
2synthesis methods
- Product Name:2-Propanone, 1-chloro-3-(4-fluorophenyl)-
- CAS Number:303967-88-6
- Molecular formula:C9H8ClFO
- Molecular Weight:186.61
Yield:303967-88-6 95%
Reaction Conditions:
Stage #1: p-Fluorophenylacetic acidwith isopropylmagnesium chloride in tetrahydrofuran;tert-butyl methyl ether at -10 - 25; for 1.5 h;Inert atmosphere;Schlenk technique;
Stage #2: 2-chloro-N-methoxy-N-methylacetamide in tetrahydrofuran;tert-butyl methyl ether at 0 - 5; for 1.25 h;Inert atmosphere;Schlenk technique;
References:
Zacuto, Michael J.;Dunn, Robert F.;Figus, Margaret [Journal of Organic Chemistry,2014,vol. 79,# 18,p. 8917 - 8925] Location in patent:supporting information
