2-Propynoic acid, 3-(2-thienyl)-, methyl ester synthesis

6synthesis methods

Product Name:2-Propynoic acid, 3-(2-thienyl)-, methyl ester
CAS Number:6824-26-6
Molecular formula:C8H6O2S
Molecular Weight:166.2

3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID METHYL ESTER

134568-16-4
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2-Propynoic acid, 3-(2-thienyl)-, methyl ester

6824-26-6
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Yield:6824-26-6 78%

Reaction Conditions:

Stage #1: methyl 3-oxo-3-(thien-2-yl)propanoatewith lithium hexamethyldisilazane in tetrahydrofuran;ethylbenzene at -70; for 0.5 h;Inert atmosphere;
Stage #2: with diethyl chlorophosphate in tetrahydrofuran;ethylbenzene at -78 - 20; for 0.5 h;Inert atmosphere;
Stage #3: with lithium hexamethyldisilazane in tetrahydrofuran;ethylbenzene at -78; for 1 h;Inert atmosphere;

References:

Shu, Fan;Zheng, Qingjuan;Dong, Wanrong;Peng, Zhihong;An, Delie [Canadian Journal of Chemistry,2017,vol. 95,# 2,p. 144 - 148]

4298-52-6 Synthesis