3-Methyl-1H-indazole-6-carboxylic acid methyl ester synthesis
- Product Name:3-Methyl-1H-indazole-6-carboxylic acid methyl ester
- CAS Number:201286-95-5
- Molecular formula:C10H10N2O2
- Molecular Weight:190.2
67-56-1
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Yield:201286-95-5 87%
Reaction Conditions:
with sulfuric acid for 22 h;Heating / reflux;
Steps:
39.4 Preparation Example 39-4 6-(Methoxycarbonyl)-3-methyl-1H-indazole
Preparation Example 39-4 6-(Methoxycarbonyl)-3-methyl-1H-indazole 6-Carboxy-3-methyl-1H-indazole (359 mg, 2.11 mmol) was dissolved in methanol (50 ml), and concentrated sulfuric acid (0.1 ml) was added.. The mixture was heated under reflux for 22 hr.. After cooling, a saturated aqueous sodium hydrogencarbonate solution was added and the methanol was distilled away under reduced pressure.. The residue was extracted with ethyl acetate, and the organic layer was washed with saturated brine and dried over anhydrous sodium sulfate.. The drying agent was filtered off and the filtrate was concentrated under reduced pressure to give the objective compound (340 mg, 87%) as brown crystals. 1H-NMR(CDCl3, δ ppm): 8.18(1H, s), 7.82(1H, d, J=8.4 Hz), 7.72(1H, d, J=8.4 Hz), 3.96(3H, s), 2.61(3H, s).
References:
US6348474,2002,B1 Location in patent:Page column 81
24812-93-9
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108-24-7
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201286-95-5
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24812-93-9
18 suppliers
$425.00/1g
201286-95-5
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201286-96-6
38 suppliers
$119.00/500mg
201286-95-5
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103440-95-5
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