4-(3-AMINO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER synthesis
- Product Name:4-(3-AMINO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS Number:206879-72-3
- Molecular formula:C15H23N3O2
- Molecular Weight:277.36
206879-94-9
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$496.64/5MG
206879-72-3
67 suppliers
$18.00/100mg
Yield: 95%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanolInert atmosphere;
Steps:
1 tert-Butyl 4-(3-aminophenyl)piperazine-l-carboxylate (15d)
To a solution of 15d* (700 mg, 2.27 mmol) in CH3OH (15 mL) was added 10% Pd/C (200 mg) in excess and (g) was passed through latex valve bladder for overnight. The reaction mixture was then filtered through celite and concentrated to afford 15d (600 mg, 95%) as brown viscous liquid which was used in next step without purification.
References:
UNIVERSITY OF HOUSTON SYSTEM;TRUSTEES OF TUFTS COLLEGE;CUNY, Gregory;NIKHAR, Sameer;DEGTEREV, Alexei WO2018/213219, 2018, A1 Location in patent:Paragraph 0178-0179; 0014
24424-99-5
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$13.50/25G
206879-72-3
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$18.00/100mg
402-67-5
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$6.00/5g
206879-72-3
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$18.00/100mg
57260-71-6
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$5.00/5g
206879-72-3
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$18.00/100mg
54054-85-2
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$17.67/1gm:
206879-72-3
67 suppliers
$18.00/100mg