2-((tert-Butoxycarbonyl)amino)propane-1,3-diyl dimethanesulfonate synthesis
- Product Name:2-((tert-Butoxycarbonyl)amino)propane-1,3-diyl dimethanesulfonate
- CAS Number:213475-70-8
- Molecular formula:C10H21NO8S2
- Molecular Weight:347.41
Yield:213475-70-8 97%
Reaction Conditions:
with triethylamine in dichloromethane at 0 - 20; for 2 h;
Steps:
40.2 Step 2
To a solution of tert-butyl (1,3-dihydroxypropan-2-yl)carbamate (21.0 g, 0.1 mol) andTEA (23.0 g, 0.2 mol) in dry CI-bCb (200 mL) was added MsCl (26.0 g, 0.2 mol) at 0 °C. Afterthe stirring at room temperature for 2 hrs, the reaction was filtered. The filtrate was concentratedto dryness to give crude 2-((tert-butoxycarbonyl)amino)propane-1,3-diyl dimethanesulfonate(37.0 g, yield: 97%) as a white solid which was used for next step directly without anypurification.
References:
WO2018/136890,2018,A1 Location in patent:Paragraph 00801; 00803
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