2-tert-Butyl-4-(piperazin-1-yl)-6-trifluoromethyl-pyrimidine synthesis
- Product Name:2-tert-Butyl-4-(piperazin-1-yl)-6-trifluoromethyl-pyrimidine
- CAS Number:219599-99-2
- Molecular formula:C13H19F3N4
- Molecular Weight:288.31
110-85-0
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1722-12-9
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219599-99-2
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$114.00/100mg
Yield:-
Reaction Conditions:
in ethanol;water;
Steps:
1 2-t-Butyl-4-(1-piperazinyl)-6-trifluoromethylpyrimidine (3)
2-t-Butyl-4-(1-piperazinyl)-6-trifluoromethylpyrimidine (3) A solution of 60 g (0.25 mol) of the chloropyrimidine described above in 200 ml of ethanol was added dropwise to a boiling solution of 129 g (1.5 mol) of piperazine in 500 ml of ethanol over the course of 2 h, and then the mixture was boiled for a further 6 h. After the reaction was complete, the solvent was removed under reduced pressure, and the residue was mixed with 2 l of water. The product crystallized on cooling and was then filtered off with suction. 1H-NMR (250 MHz, CDCl3): δ=1.3 (s, 9H); 1.8 (s, 1H); 3.0 (m, 4H); 4.7 (m, 4H); 6.6 (s, 1H) ppm.
References:
US2001/20022,2001,A1
110-85-0
587 suppliers
$5.00/5G
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219599-99-2
36 suppliers
$114.00/100mg