METHYL 4-OXO-4H-PYRIDO[1,2-A]PYRIMIDINE-2-CARBOXYLATE synthesis
- Product Name:METHYL 4-OXO-4H-PYRIDO[1,2-A]PYRIMIDINE-2-CARBOXYLATE
- CAS Number:23951-66-8
- Molecular formula:C10H8N2O3
- Molecular Weight:204.18
Yield:23951-66-8 82%
Reaction Conditions:
in water at 20; for 6 h;Solvent;Temperature;Time;Reagent/catalyst;
Steps:
3aa
General procedure: A flaskwas charged with 1 (0.32 mmol) andwater (30 mL). Then2 (0.38 mmol) was added to the reaction system. The reaction wasstirred at room temperature for 6 h in air. Then the reaction wasextracted with CH2Cl2 (20 mL) and dried over anhydrous Na2SO4.After the solvent was evaporated in vacuo, the residues were purifiedby column chromatography, eluting with petroleum ether(PE)eEtOAc to afford pure 3.
References:
Yan, Hao;Ma, Ying;Sun, Yuanjun;Ma, Chao;Wang, Yuling;Ren, Xiaoyu;Huang, Guosheng [Tetrahedron,2014,vol. 70,# 17,p. 2761 - 2765]
