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259133-67-0

5,6-Dihydro-4H-pyridine-1,2-dicarboxylic acid 1-tert-butyl ester synthesis

6synthesis methods
-

Yield:259133-67-0 80%

Reaction Conditions:

Stage #1: tert-butyl 3-methoxypiperidine-1-carboxylatewith N,N,N,N,-tetramethylethylenediamine;sec.-butyllithium in tetrahydrofuran;
Stage #2: carbon dioxide in tetrahydrofuran;

References:

Hanessian, Stephen;Yang, Gaoqiang;Rondeau, Jean-Michel;Neumann, Ulf;Betschart, Claudia;Tintelnot-Blomley, Marina [Journal of Medicinal Chemistry,2006,vol. 49,# 15,p. 4544 - 4567]