(2E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one synthesis
- Product Name:(2E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one
- CAS Number:2403-27-2
- Molecular formula:C15H11BrO
- Molecular Weight:287.15
108-86-1
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102-92-1
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2403-27-2
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Yield: 86%
Reaction Conditions:
with zinc(II) oxide at 25 - 30; for 2 h;regioselective reaction;Friedel-Crafts Acylation;
Steps:
General procedure: A mixture of α,β-unsaturated acid chloride (501 mg, 3 mmol), an aromatic compound (324 mg, 3 mmol) and zinc oxide (120 mg, 1.5 mmol) was stirred at room temperature (25-30 °C) for the specified time (Table 2). The progress of the reaction was monitored by TLC. After completion of the reaction, the product was extracted with dichloromethane (3 × 5 mL), and extract was washed with aq. NaHCO3. The organic layer was dried over anhydrous Na2SO4 and removal of the solvent under reduced pressure furnished analytically pure product with 92% yield (219 mg).
References:
More, Parmeshwar E.;Bandgar, Babasaheb P.;Kamble, Vinod T. [Catalysis Communications,2012,vol. 27,p. 30 - 32]
99-90-1
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100-52-7
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2403-27-2
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$116.64/1gm:
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1000210-73-0
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2403-27-2
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100-42-5
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201230-82-2
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66107-30-0
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2403-27-2
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