ChemicalBook CAS DataBase List (2RS)-2-(4-FORMYLPHENYL)PROPANOIC ACID

(2RS)-2-(4-FORMYLPHENYL)PROPANOIC ACID synthesis

6synthesis methods

Product Name:(2RS)-2-(4-FORMYLPHENYL)PROPANOIC ACID
CAS Number:43153-07-7
Molecular formula:C10H10O3
Molecular Weight:178.19

111128-12-2 Synthesis

111128-12-2
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43153-07-7
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Yield:-

Reaction Conditions:

Stage #1:2-[4-(bromomethyl)phenyl]propanoic acid with hexamethylenetetramine in chloroform at 63 - 65; for 6 h;
Stage #2: with hydrogenchloride in chloroform;water for 2 h;Reflux;

Steps:

2.1 Example 2
To 500ml three-necked flask,Para-bromomethyl isophthalic acid (96.84 g, 0.40 mol) was added,Hexamethylenetetramine (112.1 g, 0.80 mol),Chloroform 240ml, stirring heated to reflux (63 ~ 65 ),Stirring reaction 6h,Sampling point plate reaction is complete,Cooled to room temperature,Join 36% concentrated hydrochloric acid 60g, stirring heated to reflux for 2h,After cooling to room temperature, the organic layer was separated and the organic layer was washed with 200 ml of saturated sodium carbonate aqueous solution,Layered organic layer,Concentrate to dryness under reduced pressure67.56 g of 2- (4-formylphenyl) propionic acid as a pale yellow solid,Yield 94.2% HPLC purity 94.6%.

References:

Weihai Disu Pharmaceutical Co., Ltd.;Disha Pharmaceutical Group Co., Ltd.;Liu Yanbin;Cai Yahui;Wu Yanhua;Bi Kexing;Li Dajun CN107353195, 2017, A Location in patent:Paragraph 0014

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