ChemicalBook CAS DataBase List 2-(4-Methylphenyl)propanoic acid

2-(4-Methylphenyl)propanoic acid synthesis

14synthesis methods

Product Name:2-(4-Methylphenyl)propanoic acid
CAS Number:938-94-3
Molecular formula:C10H12O2
Molecular Weight:164.2

75920-45-5 Synthesis

75920-45-5
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938-94-3
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Yield:938-94-3 92%

Reaction Conditions:

with sodium hydroxide at 100 - 105;

Steps:

1.4 Step 4
Add 14.5 g of compound III to a 250 mL three-necked flask.3 mol/L sodium hydroxide solution 100 g,The reaction is refluxed at 100-105 ° C for 8 - 10 h, the reaction is completed, the temperature is reduced to room temperature, acidified to pH 2.0 - 3.0 with hydrochloric acid, extracted with toluene, the organic phase is washed with water, dried over anhydrous sodium sulfate, filtered and evaporated. , adding n-hexane, crystallization,15 g of the compound 2-(4-methyl)phenylpropionic acid (IV) was obtained as a white solid, yield 92%, HPLC. Purity is 98%

References:

Panjin Ge Linkaimo Technology Co., Ltd.;Gong Ningrui CN109809962, 2019, A Location in patent:Paragraph 0011

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622-97-9 Synthesis