3-(1-Methyl-1H-pyrazol-4-yl)quinolin-6-aMine synthesis
- Product Name:3-(1-Methyl-1H-pyrazol-4-yl)quinolin-6-aMine
- CAS Number:1184919-71-8
- Molecular formula:C13H12N4
- Molecular Weight:224.26
1431930-27-6
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1184919-71-8
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Yield:1184919-71-8 100%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in ethanol at 20;
Steps:
4.1.2.1.2. General procedure of reduction of nitro compounds toamines (Method B)
General procedure: Respected quinaxoline-nitro compound (1 eq)was dissolved in EtOH followed by the addition of Pd/C (10% w/w)under inert conditions. The reaction mixture was stirred under H2atmosphere for 4-12 h at room temperature. After completion ofreaction, the mixture was filtered through Celite and solvent wasevaporated under reduced pressure to yield correspondingquinaxoline-amine which were used without purification for nexttransformations (85-99%).
References:
Sagar, Satish;Singh, Sarbjit;Mallareddy, Jayapal Reddy;Sonawane, Yogesh A.;Napoleon, John V.;Rana, Sandeep;Contreras, Jacob I.;Rajesh, Christabelle;Ezell, Edward L.;Kizhake, Smitha;Garrison, Jered C.;Radhakrishnan, Prakash;Natarajan, Amarnath [European Journal of Medicinal Chemistry,2021,vol. 222,art. no. 113579]
7101-95-3
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613-50-3
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$10.00/5g
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100-01-6
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$11.19/25G
1184919-71-8
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