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4-Nitroaniline structure
Chemical Name:
PNA;red2gbase;developerp;devolredgg;NCI-C60786;AKOS 92446;4-Nitroani;Developer P;Red 2G Base;+Kitronnilin
Molecular Formula:
Formula Weight:
MOL File:

4-Nitroaniline Properties

Melting point:
147 °C
Boiling point:
332 °C
1,437 g/cm3
vapor pressure 
1.33 hPa (142 °C)
refractive index 
1.6465 (estimate)
Flash point:
329 °F
storage temp. 
Store at R.T.
ethanol: soluble25mg/mL, slightly hazy, yellow to brownish-yellow
Colour Index 
1(at 25℃)
Specific Gravity
Water Solubility 
0.8 g/L (20 ºC)
Stable. Incompatible with sodium hydroxide, strong oxidizing agents, strong reducing agents. May attack some plastics, rubber and coatings. May decompose explosively in the presence of initiators. Moisture sensitive. May be light and air-sensitive.
CAS DataBase Reference
100-01-6(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
Benzenamine, 4-nitro-(100-01-6)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
  • NFPA
Hazard Codes  T,F
Risk Statements  23/24/25-33-52/53-39/23/24/25-11
Safety Statements  28-36/37-45-61-28A-16-1/2-7
RIDADR  UN 1661 6.1/PG 2
WGK Germany  2
RTECS  BY7000000
Autoignition Temperature 500 °C
Hazard Note  Toxic
HazardClass  6.1
PackingGroup  II
HS Code  29214210
Hazardous Substances Data 100-01-6(Hazardous Substances Data)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger P264, P270, P301+P310, P321, P330,P405, P501
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H310 Fatal in contact with skin Acute toxicity,dermal Category 1, 2 Danger P262, P264, P270, P280, P302+P350,P310, P322, P361, P363, P405, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H330 Fatal if inhaled Acute toxicity,inhalation Category 1, 2 Danger P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H402 Harmful to aquatic life Hazardous to the aquatic environment, acute hazard Category 3
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P320 Specific treatment is urgent (see … on this label).
P330 Rinse mouth.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P405 Store locked up.

NFPA 704

Diamond Hazard Value Description
3 3
HEALTH   3 Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
FIRE  1 Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
REACT   3 Capable of detonation or explosive decomposition but requires a strong initiating source, must be heated under confinement before initiation, reacts explosively with water, or will detonate if severely shocked (e.g. ammonium nitrate, cesium, hydrogen peroxide)

(NFPA, 2010)

4-Nitroaniline price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 185310 4-Nitroaniline ≥99% 100-01-6 5g $21.9 2018-11-13 Buy
Sigma-Aldrich 185310 4-Nitroaniline ≥99% 100-01-6 100g $35.6 2018-11-13 Buy
TCI Chemical N0119 4-Nitroaniline >98.0%(GC) 100-01-6 25g $18 2018-11-22 Buy
TCI Chemical N0119 4-Nitroaniline >98.0%(GC) 100-01-6 500g $108 2018-11-22 Buy
Alfa Aesar A10369 4-Nitroaniline, 98% 100-01-6 1000g $64.4 2018-11-13 Buy

4-Nitroaniline Chemical Properties,Uses,Production

Chemical Properties

Yellow fine crystals

Chemical Properties

p-Nitroaniline consists of yellow crystals with a pungent, faint ammonia-like odor.


Product of chromogenic reactions.


4-Nitroaniline is used in the synthesis of photorefractive polymers, as novel chromophores in analytical study. As well, due to the absorption spectrum associated with 4-Nitroaniline, it is used to de termine catechol derivatives in syntheses.


ChEBI: A nitroaniline carrying a nitro group at position 4.


Dyestuff intermediate.

General Description

Yellow solid with a mild odor. Sinks in water.

Air & Water Reactions

4-Nitroaniline may be sensitive to prolonged exposure to air and light. Insoluble in water. 4-Nitroaniline is sensitive to moisture.

Reactivity Profile

P-NITROANILINE may react vigorously with sulfuric acid above 392° F. 4-Nitroaniline may also react with sodium hydroxide at 266° F. Under pressure, 4-Nitroaniline may produce an explosive compound. 4-Nitroaniline is incompatible with strong oxidizers and strong reducing agents. 4-Nitroaniline is capable of explosive decomposition with strong initiators. 4-Nitroaniline will attack some forms of plastics, rubber and coatings.


Explosion risk. Toxic when absorbed by skin. Methemoglobinemia, liver damage and eye irritant. Questionable carcinogen.

Health Hazard

Inhalation or ingestion causes headache, drowsiness, shortness of breath, nausea, methemoglobinemia, and unconsciousness; fingernails, lips, and ears become bluish; prolonged and excessive exposures may also cause liver damage. Contact with eyes causes irritation and possible corneal damage. Contact with skin causes irritation; continued exposure may cause same symptoms as inhalation or ingestion.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by intramuscular route. Mutation data reported. Acute symptoms of exposure are headache, nausea, vomiting, weakness and stupor, cyanosis and methemoglobinemia. Chronic exposure can cause liver damage. Experimental reproductive effects. Combustible when exposed to heat or flame. See NITRATES for explosion and disaster hazards. To fight fire, use water spray or mist, foam, dry chemical, CO2. Vigorous reaction with sulfuric acid above 200°C. Reaction with sodium hydroxide at 13O°C under pressure may produce the explosive sodium-4-nitrophenoxide. When heated to decomposition it emits toxic fumes of NOx. See also m- NITROANILINE, o-NITROANILINE, NITRO COMPOUNDS OF AROMATIC HYDROCARBONS, and ANILINE DYES.

Potential Exposure

p-Nitroaniline is used as an intermediate in the manufacture of dyes; antioxidants, pharmaceuticals, and pesticides.

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.


UN1661 Nitroanilines (m-, o-, p-), Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

It also crystallises from acetone. It is freed from o-and m-isomers by zone melting and sublimation. [Beilstein 12 IV 1613.]


A combustible liquid. A strong oxidizer. Incompatible with strong acids; sulfur, combustibles, organics, and other easily oxidizable materials. Will accelerate the burning of combustible materials. If large quantities are involved in a fire or the combustible material is finely divided, an explosion may result. Prolonged exposure to fire or heat may result in an explosion.

Waste Disposal

Incineration (982℃, 2.0 seconds minimum) with scrubbing for nitrogen oxides abatement. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

4-Nitroaniline Preparation Products And Raw materials

Raw materials

Preparation Products

4-Nitroaniline Suppliers

Global( 302)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32651 55
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 CHINA 16534 60
Anhui Royal Chemical Co., Ltd.
+86-025-86736275 CHINA 486 55
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 24118 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254 CHINA 20229 58
career henan chemical co
+86-371-86658258 CHINA 19997 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 China 25106 65
ShangHai Siyan Biological Technology Co., Ltd. 021-50908862,18800375331,18721037013,QQ: 442785678, QQ:1940135426
021-50908862 , China 9637 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) China 40395 62

View Lastest Price from 4-Nitroaniline manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-30 4-Nitroaniline
US $1.00 / KG 1G 98% 100kg career henan chemical co

4-Nitroaniline Spectrum

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