3-(2-BENZOTHIAZOLYLTHIO)PROPIONIC ACID synthesis
- Product Name:3-(2-BENZOTHIAZOLYLTHIO)PROPIONIC ACID
- CAS Number:4767-00-4
- Molecular formula:C10H9NO2S2
- Molecular Weight:239.31
Yield: 100%
Reaction Conditions:
Stage #1:2-Mercaptobenzothiazole with potassium carbonate in tetrahydrofuran for 0.166667 h;Inert atmosphere;
Stage #2:3-Bromopropionic acid in tetrahydrofuran at 20;Inert atmosphere;
Steps:
Compound 3 was obtained in quantitative yield as an off-whitesolid. 2-Marcaptobenzothiazol (670 mg) was dissolved in THF(10 mL), potassium carbonate (1.1 g) was added, and the reaction wasstirred for 10 min under argon. Then 3-bromoproponic acid (910 mg)was added. The reaction was allowed to stir overnight at room temperatureunder argon. The reaction was neutralized with 2 M HCl and theproduct was extracted with DCM.
References:
Berkman, Clifford E.;Chen, Wei;Knight, Jessica Renee;Wang, Yingying;Xian, Ming;Xu, Shi [Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2021,vol. 247,art. no. 119072]
57-57-8
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