ChemicalBook CAS DataBase List 3,4-DIFLUOROBENZOYLACETONITRILE

3,4-DIFLUOROBENZOYLACETONITRILE synthesis

5synthesis methods

Product Name:3,4-DIFLUOROBENZOYLACETONITRILE
CAS Number:71682-97-8
Molecular formula:C9H5F2NO
Molecular Weight:181.14

76903-88-3
154 suppliers
$8.00/1g

75-05-8 Synthesis

75-05-8
961 suppliers
$10.00/10g

71682-97-8
69 suppliers
inquiry

Yield:71682-97-8 97%

Reaction Conditions:

Stage #1: acetonitrilewith lithium diisopropyl amide in tetrahydrofuran at -78; for 0.5 h;
Stage #2: 3,4-difluorobenzoyl chloride in tetrahydrofuran at 20; for 4 h;

References:

Rai, Ganesha;Brimacombe, Kyle R.;Mott, Bryan T.;Urban, Daniel J.;Hu, Xin;Yang, Shyh-Ming;Lee, Tobie D.;Cheff, Dorian M.;Kouznetsova, Jennifer;Benavides, Gloria A.;Pohida, Katie;Kuenstner, Eric J.;Luci, Diane K.;Lukacs, Christine M.;Davies, Douglas R.;Dranow, David M.;Zhu, Hu;Sulikowski, Gary;Moore, William J.;Stott, Gordon M.;Flint, Andrew J.;Hall, Matthew D.;Darley-Usmar, Victor M.;Neckers, Leonard M.;Dang, Chi V.;Waterson, Alex G.;Simeonov, Anton;Jadhav, Ajit;Maloney, David J. [Journal of Medicinal Chemistry,2017,vol. 60,# 22,p. 9184 - 9204] Location in patent:supporting information