3,4-METHYLENEDIOXYCHALCONE synthesis
- Product Name:3,4-METHYLENEDIOXYCHALCONE
- CAS Number:644-34-8
- Molecular formula:C16H12O3
- Molecular Weight:252.26
Yield:644-34-8 95%
Reaction Conditions:
with sodium hydroxide in methanol at 20; for 48 h;Inert atmosphere;Claisen-Schmidt Condensation;
Steps:
3.2. Synthesis of Chalcones
General procedure: To the mixture of a commercial benzaldehyde (1.2 mmol), acetophenone 1a or 1b(1.22 and 2.08 mmol) in MeOH (5 mL), a NaOH saturated solution, was added (in 10 mLof methanol), and the mixture was stirred for 48 h at room temperature. After the disappearanceof the reactant (TLC), 5% HCl solution was added until pH ~7 to end the reaction,the mixture was extracted with EtOAc (3 50 mL), and the combined organic layers weredried (anhydrous Na2SO4). Removal of the solvent and purification of the residue bycolumn chromatography or recrystallization gave the target products
References:
Bustos, Luis;Echiburú-Chau, Carlos;Castro-Alvarez, Alejandro;Bradshaw, Ben;Simirgiotis, Mario J.;Mellado, Marco;Parra, Claudio;Cuellar, Mauricio [Molecules,2022,vol. 27,# 14,art. no. 4387]
139-85-5
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$5.00/1g
644-34-8
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$37.00/1g
