3-(5-CHLORO-THIOPHEN-2-YL)-3-OXO-PROPIONITRILE synthesis
- Product Name:3-(5-CHLORO-THIOPHEN-2-YL)-3-OXO-PROPIONITRILE
- CAS Number:71683-01-7
- Molecular formula:C7H4ClNOS
- Molecular Weight:185.63
Yield:-
Reaction Conditions:
with sodium methylate in methanol;Inert atmosphere;Reflux;Claisen Condensation;
Steps:
5.2.4 Synthesis of 3-(5-halide thiophene-2-yl)-3-oxopropanenitrile
General procedure: 5-halide thiophene-2-carboxylate (1equiv) was solved under inert conditions in absolute acetonitrile, and sodium methoxide (2equiv, freshly prepared) was added. The reaction stirred under reflux conditions overnight and was diluted with purified water, afterwards. The aqueous phase was extracted with dichloromethane. The organic layer was dried over MgSO4, filtrated and the solvent was evaporated under reduced pressure. The white solid phase was used without any further purification.
References:
Hauck, Stefanie;Hiesinger, Kerstin;Khageh Hosseini, Sabrina;Achenbach, Janosch;Biondi, Ricardo M.;Proschak, Ewgenij;Z?rnig, Martin;Odadzic, Dalibor [Bioorganic and Medicinal Chemistry,2016,vol. 24,# 22,p. 5717 - 5729]
24065-33-6
736 suppliers
$6.00/5g
71683-01-7
19 suppliers
inquiry
6310-09-4
199 suppliers
$9.00/5g
71683-01-7
19 suppliers
inquiry
42445-55-6
15 suppliers
$90.00/50mg
151-50-8
4 suppliers
$43.36/100g
71683-01-7
19 suppliers
inquiry