3,5-DIMETHOXYPHENYLACETIC ACID synthesis
- Product Name:3,5-DIMETHOXYPHENYLACETIC ACID
- CAS Number:4670-10-4
- Molecular formula:C10H12O4
- Molecular Weight:196.2
1141493-97-1
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4670-10-4
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Yield:4670-10-4 100%
Reaction Conditions:
with triethylsilane;trifluoroacetic acid in dichloromethane at 0; for 3 h;
Steps:
teri-Butyl 2-(3,5-dimethoxyphenyl)acetate (18 mg, 0.071 mmol) was dissolved in CH2CI2 (3 mL) and cooled to 0 °C. Triethylsilane (28 μ, 0.18 mmol) was added, followed by trifluoroacetic acid (60 μ, 0.92 mmol) and the mixture was stirred at 0 °C for 3 h. The reaction mixture was dried under reduced pressure to give the title compound as a yellow oil (14 mg, 100%). NMR (400 MHz, CDCh) δ 6.73 (d, / = 2.3 Hz, 2 H), 6.48 (t, J = 2.01 Hz, 1 H), 3.86 (s, 6 H), 3.77 (s, 2 H).
References:
WO2011/123937,2011,A1 Location in patent:Page/Page column 78
6512-32-9
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4670-10-4
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201230-82-2
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39151-19-4
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4670-10-4
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