3,7-DiMethyl-1H-indazole-5-carboxylic acid synthesis
- Product Name:3,7-DiMethyl-1H-indazole-5-carboxylic acid
- CAS Number:1031417-75-0
- Molecular formula:C10H10N2O2
- Molecular Weight:190.2
1031417-71-6
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199620-15-0
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Yield:1031417-75-0 17%
Reaction Conditions:
Stage #1: 5-bromo-3,7-dimethyl-1H-indazole;molybdenum hexacarbonylwith sodium carbonate;trans-bis(acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium in 1,4-dioxane;water at 165; for 0.25 h;
Stage #2: with hydrogenchloride in 1,4-dioxane;water; pH=2;
Steps:
10
To a reaction vessel containing a re-purified solution of 5-bromo-3,7-dimethyl-1 H-indazole (prepared as described for Acid Preparation 8, 285 mg, 1.27 mmol) in dioxane (1.3 mL) was added hexacarbonylmolybdenum (264 mg, 1.0 mmol), Herrmann's catalyst (93 mg, 0.1 mmol)and a solution of
References:
WO2008/65508,2008,A1 Location in patent:Page/Page column 31-32
70598-49-1
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1031417-71-6
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$186.00/100mg
497-19-8
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24549-06-2
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