3-AMINO-5-NITROBENZOIC ACID METHYL ESTER synthesis
- Product Name:3-AMINO-5-NITROBENZOIC ACID METHYL ESTER
- CAS Number:23218-93-1
- Molecular formula:C8H8N2O4
- Molecular Weight:196.16
67-56-1
618-84-8
23218-93-1
General procedure for the synthesis of methyl 3-amino-5-nitrobenzoate from methanol and 3-amino-5-nitrobenzoic acid: The esterification reaction was carried out by passing dry hydrogen chloride gas into a solution of methanol (160 ml) containing 5-amino-3-nitrobenzoic acid (18.5 g, 0.10 mol). After the solution was saturated, the reaction mixture was stirred at room temperature overnight. Subsequently, the mixture was concentrated to a crystalline residue. The residue was dissolved in dichloromethane and washed with 5% sodium bicarbonate solution until the pH of the aqueous phase reached 7-8. The organic phase was separated, dried over magnesium sulfate and evaporated to remove the solvent. The product 18.6 g was obtained in 94% yield.1H NMR (CDCl3) data: δ 8.21 (t, 1H, J=1.5Hz), 4.19 (br s, 2H), 3.96 (s, 3H).
67-56-1
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618-84-8
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$30.00/1g
23218-93-1
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Yield:23218-93-1 100%
Reaction Conditions:
with acetyl chloride at 80; for 48 h;
References:
Mancuso, Lena;Juerjens, Gerrit;Hermane, Jekaterina;Harmrolfs, Kirsten;Eichner, Simone;Fohrer, Joerg;Collisi, Wera;Sasse, Florenz;Kirschning, Andreas [Organic Letters,2013,vol. 15,# 17,p. 4442 - 4445] Location in patent:supporting information
2702-58-1
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23218-93-1
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$13.00/250mg
99-33-2
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23218-93-1
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99-34-3
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$14.00/5g
23218-93-1
79 suppliers
$13.00/250mg