3-AMINO-6-METHOXYPYRIDAZINE synthesis
- Product Name:3-AMINO-6-METHOXYPYRIDAZINE
- CAS Number:7252-84-8
- Molecular formula:C5H7N3O
- Molecular Weight:125.13
5469-69-2
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124-41-4
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7252-84-8
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Yield:7252-84-8 85.7%
Reaction Conditions:
with copper in methanol at 160; for 24 h;
Steps:
15; 125.a (6-METHOXY-PYRIDAZIN-3-YL)- (2-METHYL-QUINAZOLIN-4-YL)-METHYL-AMINE; Scheme 15
3-Amino-6-methoxy-pyridazine: A mixture of 3-amino-6-chloro- pyridazin (500 mg, 3.86 MMOL), sodium methoxide (1.0 ml, 4.4 mmol, 25 % w/w) and copper powder (331 mg, 5.17 mmol) in methanol (3 ml) was heated in a sealed tube at 160 °C for 24 h. After cooling, the reaction mixture was diluted with methanol (10 ml) and filtered, and the filtrate was concentrated by vacuum. The residue was purified by chromatography on silica gel with acetate and hexane (1: 2) as eluent, yielding 413 mg of title compound (85.7 %). H NMR (CDC13) : 6.81 (M, 2H), 4.62 (brs, 2H), 4.00 (s, 3H).
References:
MYRIAD GENETICS, INC.;CYTOVIA, INC. WO2005/3100, 2005, A2 Location in patent:Page 135; 224-225
80-35-3
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7252-84-8
208 suppliers
$9.00/250mg