3-AMINO-N-(3-METHYLPHENYL)BENZAMIDE synthesis
- Product Name:3-AMINO-N-(3-METHYLPHENYL)BENZAMIDE
- CAS Number:14315-23-2
- Molecular formula:C14H14N2O
- Molecular Weight:226.27
69754-50-3
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14315-23-2
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Yield:14315-23-2 86%
Reaction Conditions:
with hydrogenchloride;tin(II) chloride dihdyrate in ethanol;water at 90; for 0.166667 h;
Steps:
4.3.2. Preparation of 19
General procedure: The corresponding 3-methyl-N-(nitrophenyl)benzamides or nitro-N-3 tolylbenzamide (18, 10 mmol) was dissolved in a mixture of dilute aqueous HCl solution (2-N, 20 mL) and EtOH (20 mL).Then, tin (II) chloride dihydrate (40 mmol) was added and the reaction mixture was heated to 90 °C until the solid completely dissolved. After 10 min of stirring at this temperature, EtOH was removed under reduced pressure. The residue was poured into EtOAc (200 mL) containing 15 g of sodium carbonate. The solution was filtered and washed with EtOAc (100 mL). The filtrate was dried over MgSO4 and concentrated under reduced pressure. The residual solid was recrystallized in EtOAc/cyclohexane (3: 2).
References:
Pillaiyar, Thanigaimalai;Funke, Mario;Al-Hroub, Haneen;Weyler, Stefanie;Ivanova, Sabrina;Schlegel, Jonathan;Abdelrahman, Aliaa;Müller, Christa E. [European Journal of Medicinal Chemistry,2020,vol. 186,art. no. 111789] Location in patent:supporting information
108-44-1
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14315-23-2
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121-90-4
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14315-23-2
14 suppliers
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