3-(benzyloxy)benzonitrile(SALTDATA: FREE) synthesis
- Product Name:3-(benzyloxy)benzonitrile(SALTDATA: FREE)
- CAS Number:61147-43-1
- Molecular formula:C14H11NO
- Molecular Weight:209.24
Yield:61147-43-1 780 mg
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide; for 42 h;
Steps:
71 3-(Benzyloxy)benzonitrile
A mixture of 3-hydroxybenzonitrile (504 mg, 4.24 mmol), benzyl chloride (607 mg, 4.78 mmol), and K2C03 (605 mg, 4.38 mmol) in 2 mL of DMF reacted for 42 hr. The mixture was diluted with 50% EA/Hex and washed with 5% Na2C03 (2x) and brine made acidic with 1M HC1. The organic phase was dried over anhydrous MgS04 and concentrated. FC (15% EA/Hex) gave 780 mg of colorless oil. R O.50 (20% EA/Hex); 1H NMR (CDC13) δ 7.43-7.31 (m, 6H), 7.26-7.17 (m, 3H), 5.08 (m, 2H, AB).
References:
WO2014/120995,2014,A2 Location in patent:Page/Page column 139
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