3-Bromo-2-fluorobenzoic acid methyl ester synthesis
- Product Name:3-Bromo-2-fluorobenzoic acid methyl ester
- CAS Number:206551-41-9
- Molecular formula:C8H6BrFO2
- Molecular Weight:233.03
1007-16-5
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74-88-4
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206551-41-9
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Yield: 89.5%
Reaction Conditions:
with potassium carbonate in tert-butyl methyl ether;N,N-dimethyl-formamide at 20; for 16 h;
Steps:
2.1
To a 100 mL round bottom flask was added 3-bromo-2-fluorobenzoic acid (5.00 g, 22.8 mmol, Oakwood), potassium carbonate (3.17 g, 22.9 mmol), and DMF (30 mL).Iodomethane, 2 M in MTBE (11.6 ml, 23.2 mmol) was added and the reaction mixture was stirred at RT for 16 hours. The reaction was filtered and the filtrate concentrated was in vacuo. The resulting brown crude residue was taken up with EtOAc and again filtered and concentrated to give methyl 3-bromo-2-fluorobenzoate (4.76 g, 20.4 mmol, 89.5% yield), as a brown syrup that was used in the Step 2 without further purification.
References:
AMGEN INC. WO2007/61930, 2007, A1 Location in patent:Page/Page column 63
67-56-1
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161957-56-8
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$6.00/1g
206551-41-9
144 suppliers
$9.00/250mg
161957-56-8
276 suppliers
$6.00/1g
149-73-5
550 suppliers
$12.00/5g
206551-41-9
144 suppliers
$9.00/250mg
161957-56-8
276 suppliers
$6.00/1g
74-88-4
355 suppliers
$15.00/10g
206551-41-9
144 suppliers
$9.00/250mg