3-BROMO-4''-METHOXYBENZOPHENONE synthesis
- Product Name:3-BROMO-4''-METHOXYBENZOPHENONE
- CAS Number:54118-76-2
- Molecular formula:C14H11BrO2
- Molecular Weight:291.14
1711-09-7
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100-66-3
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54118-76-2
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Yield:54118-76-2 84%
Reaction Conditions:
with aluminum (III) chloride in dichloromethane at 20;Inert atmosphere;
Steps:
5.A (3-bromophenyl)(4-methoxyphenyl)methylamine (5 -b)
To a cooled (0°C) mixture of 3-bromobenzoyl chloride (5-a, 178g, 0.82mol) and anisole (1 lOg, 1.03mol) in DCM (2.0L) was added AICI3 (138g, 1.03mol) portion wise with stirring under N2. The resulting reaction mixture was allowed to stir at r.t overnight. The reaction mixture was poured into 20% HC1 (1500ml), stirred for lh, and layers were separated. The aqueous layer was further extracted with DCM (2 x 750ml). The combined organic layer was washed with water, brine, dried (Na2SC"4), filtered and concentrated under reduced pressure. The residue was washed with hexane to afford the product, 5-b, (190g, 84%).
References:
WO2013/40790,2013,A1 Location in patent:Page/Page column 47; 48
3132-99-8
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5720-07-0
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54118-76-2
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2042-37-7
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6462-50-6
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54118-76-2
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585-76-2
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100-66-3
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54118-76-2
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98-68-0
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54118-76-2
35 suppliers
$45.00/50mg