ChemicalBook CAS DataBase List 3-Chloro-2-cyano-6-(trifluoromethyl)pyridine

3-Chloro-2-cyano-6-(trifluoromethyl)pyridine synthesis

5synthesis methods

Product Name:3-Chloro-2-cyano-6-(trifluoromethyl)pyridine
CAS Number:1214333-69-3
Molecular formula:C7H2ClF3N2
Molecular Weight:206.55

557-21-1 Synthesis

557-21-1
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Pyridine, 3-chloro-2-iodo-6-(trifluoroMethyl)-

823221-96-1
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3-Chloro-2-cyano-6-(trifluoromethyl)pyridine

1214333-69-3
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Yield:-

Reaction Conditions:

tetrakis(triphenylphosphine) palladium⁽⁰⁾ in N,N-dimethyl-formamide at 110;Inert atmosphere;

Steps:

104.E 3-chloro-6-(trifluoromethyl)picolinonitrile

Step E 3-chloro-6-(trifluoromethyl)picolinonitrile Into a 10-mL sealed tube purged and maintained with an inert atmosphere of nitrogen, was placed a solution of 3-chloro-2-iodo-6-(trifluoromethyl)pyridine (as prepared in the previous step, 4.0 g, 13.03 mmol, 1.00 equiv) in N,N-dimethylformamide (2 mL), Zn(CN)₂ (1.2 g, 10.34 mmol, 0.80 equiv), and Pd(PPh₃)₄ (0.8 g, 0.69 mmol, 0.05 equiv). The reaction solution was stirred overnight at 110° C. The resulting mixture was concentrated under vacuum and purified by silica gel column chromatography with ethyl acetate/petroleum ether (1:100). The title compound was obtained as yellow oil

References:

US2011/306592,2011,A1 Location in patent:Page/Page column 92

244221-57-6 Synthesis