3-Chloro-2-fluorobenzaldehyde synthesis
- Product Name:3-Chloro-2-fluorobenzaldehyde
- CAS Number:85070-48-0
- Molecular formula:C7H4ClFO
- Molecular Weight:158.56
261723-30-2
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$32.00/1g
85070-48-0
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$10.00/5g
Yield:85070-48-0 91%
Reaction Conditions:
with sodium hypochlorite;2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;sodium hydrogencarbonate in dichloromethane at 0 - 5; for 1 h;Temperature;
Steps:
29 Preparation of 2-fluoro-3-chlorobenzaldehyde
1L four-necked flask, 36.3 g of sodium hydrogencarbonate, 500 g of dichloromethane, 0.5 g of ΤΕΜΡO, and the mixture was cooled to 0 to 5 ° C with stirring, 50 g of 2-fluoro-3-chlorobenzyl alcohol and 100 g of dichloromethane were added dropwise, and then add the sodium hypochlorite solution 230g, drop after the insulation reaction 1 h, sampling control, raw materials ≤ 1%, stop the reaction, standing stratification, the oil layer of simple distillation of dichloromethane recovery, and then vacuum distillation that 2-fluoro-3-chlorobenzaldehyde 46.1 g, content 97.5%, yield 91%.
References:
CN104529729,2016,B Location in patent:Paragraph 0087; 0088
6574-97-6
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85070-48-0
254 suppliers
$10.00/5g
94087-40-8
184 suppliers
$10.00/5g
85070-48-0
254 suppliers
$10.00/5g