3-Ethyl-2,3-dihydrobenzothiazol-2-on synthesis
- Product Name:3-Ethyl-2,3-dihydrobenzothiazol-2-on
- CAS Number:6468-14-0
- Molecular formula:C9H9NOS
- Molecular Weight:179.24
Yield:6468-14-0 84%
Reaction Conditions:
with potassium hydroxide in tetrahydrofuran at 0 - 20; for 3 h;Reagent/catalyst;Solvent;
Steps:
1.1
(1) 2-hydroxybenzothiazole (1 mol, 151 g), 2-bromoethane (1.1 mol, 120 g) and potassium hydroxide (1 mol, 56) dissolved in 2L of tetrahydrofuran, stirred at 0 ° C for 1 hour, then at room temperature for 2 hours, the reaction is completed, spin fourHydrogen furan solvent, add 2 L of ethyl acetate, wash twice with water, dry over anhydrous sodium sulfate, then EtOAcCrystallization of tert-butyl ether gave 150 g of 3-ethylbenzothiazol-2-one in a yield of 84%
References:
CN108752289,2018,A Location in patent:Paragraph 0018; 0019
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