3-Fluoro-4-methylbenzonitrile synthesis
- Product Name:3-Fluoro-4-methylbenzonitrile
- CAS Number:170572-49-3
- Molecular formula:C8H6FN
- Molecular Weight:135.14
942282-44-2
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Yield:170572-49-3 89%
Reaction Conditions:
with calcium chloride in N,N-dimethyl acetamide;water at 140 - 145;
Steps:
3 Example 3: Synthesis of 3-fluoro-4-methylbenzonitrile:
A 50 mL four-necked flask was charged with 1.0 g of methyl 2-fluoro-4-cyanophenylacetate, 0.19 g of water was added,1.15 grams of 95% anhydrous calcium chloride and 15 grams of N, N-dimethylacetamide, stirring warming,140 ~ 145 incubated for 20 to 24 hours (HPLC monitoring, the conversion rate> 99%),The mixture was cooled to 60-70 ° C, concentrated under reduced pressure and purified by column chromatography to give 3-fluoro-4-methylbenzonitrile and 0.62 g of a pale yellow solid in a yield of 89.0%.
References:
CN107673994,2018,A Location in patent:Paragraph 0063; 0064; 0065
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