3-(FMOC-4-AMINOPHENYL)-PROPIONIC ACID synthesis
- Product Name:3-(FMOC-4-AMINOPHENYL)-PROPIONIC ACID
- CAS Number:882847-07-6
- Molecular formula:C24H21NO4
- Molecular Weight:387.43
2393-17-1
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28920-43-6
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882847-07-6
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$226.41/1g
Yield:882847-07-6 80%
Reaction Conditions:
with sodium hydrogencarbonate in tetrahydrofuran;water at 20; for 8 h;Cooling with ice;
Steps:
2 FMoc-3-(4-aminophenyl)propionic acid 10b
FMoc-3-(4-aminophenyl)propionic acid 1 Ob (n=2): 3-(4- aminophenyl)propionic acid (250 mg, 1.5 mmol) in a 10 mEflask was dissolved in a mixture of 10% aqueous sodium bicarbonate (0.32 mE) and tetrahydrofuran (2.2 mE) then cooled in an ice/water bath. 9-fluorenylmethyl chloroformate (422 mg, 1.5 mmol) was added in small portions over 3 mm. Afier 4 h the cooling bath was removed. After additional 4 hat room temperature, the reaction was extracted with deionized water (2 mE) and ethyl ether (2 mE) and the aqueous layer was brought to pH 4 with dilute HC1 and placed in a refrigeratot Afier 1 h solid was collected by vacuum filtration and washed with deionized water then dried under vacuum togive 470mg of product (80% yield). Mass spectrum (M+Na) calcd for C24H2,N04, 400.1. found 410.0.
References:
US9289512,2016,B2 Location in patent:Page/Page column 103; 104
2393-17-1
145 suppliers
$15.00/1g
82911-69-1
600 suppliers
$7.00/25g
882847-07-6
38 suppliers
$226.41/1g